OSIRIS is a very helpful tool for method transfer and validation since it takes into account the robustness of the analytical conditions and the dwell volume of your chromatographic equipment. The separation could be modelized versus the resolution but also integrating the Robustness in the Response function.
You can also study the effect of modifications in the physical properties of the column. Thanks to its Simulation table, OSIRIS allows you to store and to compare chromatograms obtained using different conditions. Finally, OSIRIS enables you to fully document your method and to create a detailed report.